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用来自大脑的制剂、5-甲基四氢叶酸和色胺形成色氨酸。

Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.

作者信息

Wyatt R J, Erdelyi E, DoAmaral J R, Elliott G R, Renson J, Barchas J D

出版信息

Science. 1975 Mar 7;187(4179):853-5. doi: 10.1126/science.234627.

DOI:10.1126/science.234627
PMID:234627
Abstract

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.

摘要

人脑的一种酶制剂在5-甲基四氢叶酸存在的情况下可将色胺转化为色醇(9H-1,2,3,4-四氢吡啶并[3,4-b]吲哚)。同样,N-甲基色胺和5-羟色胺分别生成1-甲基色醇和5-羟色醇。人体组织在体外或体内形成这些化合物的情况均未见报道。

相似文献

1
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.用来自大脑的制剂、5-甲基四氢叶酸和色胺形成色氨酸。
Science. 1975 Mar 7;187(4179):853-5. doi: 10.1126/science.234627.
2
Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose.通过用(14C)脱氧葡萄糖对局部代谢率进行放射自显影测量来绘制功能性神经通路图。
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Enzymatic formation of tetrahydro-beta-carboline from tryptamine and 5-methyltetrahydrofolic acid in rat brain fractions: regional and subcellular distribution.大鼠脑匀浆中色胺和5-甲基四氢叶酸酶促形成四氢-β-咔啉:区域及亚细胞分布
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5-Methyltetrahydrofolic acid as a mediator in the formation of pyridoindoles.5-甲基四氢叶酸作为吡啶并吲哚形成过程中的一种介质。
Science. 1974 Nov 22;186(4165):471-3.
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Synthesis of tetrahydro-beta-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid.通过5-甲基四氢叶酸酶促形成甲醛,由吲哚胺合成四氢-β-咔啉。
Biochem Pharmacol. 1975 Oct 1;24(19):1759-62. doi: 10.1016/0006-2952(75)90452-9.
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N-methylation of indolealkylamines in the brain with a new methyl donor.使用新型甲基供体对大脑中吲哚烷基胺进行N-甲基化。
Adv Biochem Psychopharmacol. 1974;11(0):65-74.
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Tryptolines. Formation from tryptamines and 5-MTHF by human platelets.色满卡林。由人体血小板中的色胺和5-甲基四氢叶酸形成。
Arch Gen Psychiatry. 1974 Dec;31(6):862-7. doi: 10.1001/archpsyc.1974.01760180100013.
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N5,10-methylenetetrahydrofolate reductase activity in autopsied brain parts of chronic schizophrenics and controls and in vitro tryptoline formation.
Biol Psychiatry. 1978 Dec;13(6):695-708.
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N-methyltetrahydrofolic acid: the physiological methyl donor in indoleamine N- and O-methylation.N-甲基四氢叶酸:吲哚胺N-甲基化和O-甲基化中的生理性甲基供体。
Adv Biochem Psychopharmacol. 1974;11(0):85-93.
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Regional formation of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline in rat brain extract.大鼠脑提取物中6-甲氧基-1,2,3,4-四氢-β-咔啉的区域形成
Res Commun Chem Pathol Pharmacol. 1975 Oct;12(2):355-62.

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Dietary modification of amphetamine stereotyped behaviour: the action of tryptophan, methionine, and lysine.
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