Turbes C C
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
Biomed Sci Instrum. 1999;35:297-302.
In these studies 76 mature female dogs were used. The sinal cord was transected at T6 or T8. The intercostal nerve or nerves originating cephalic to the transection were inserted into the distal isolated cord close to the transection and plasma clot sutured to anchor the peripheral end of the nerve into the spinal cord. The transected isolated spinal cord at the mid thoracic level results in rear limb paralysis. The isolated distal transected spinal cord is capable producing complex, detailed locomotor functions. The anatomical substrate is produced by systems of interconnected interneurons in the lumbar spinal cord that forms the central pattern generators (CPG). The interneurons comprising (CPG) coordinates patterned movements of the rear limbs as flexion, extension, weight bearing, postural adjustments and alternating patterned limb movements. In the case of implantation of a peripheral nerve distal stump into the transected spinal cord the procedure enhances the function mediated by the central patterned generators (CPG) by training, conditioning and chemical and molecular treatments.
在这些研究中，使用了76只成年雌性犬。脊髓在T6或T8水平横断。起源于横断部位头侧的一根或多根肋间神经被插入靠近横断部位的远端孤立脊髓，并采用血浆凝块缝合将神经外周端固定于脊髓。胸段中部水平的横断孤立脊髓会导致后肢麻痹。孤立的远端横断脊髓能够产生复杂、精细的运动功能。其解剖学基础是由腰段脊髓中相互连接的中间神经元系统形成的中枢模式发生器（CPG）。构成CPG的中间神经元协调后肢的模式化运动，如屈曲、伸展、负重、姿势调整以及交替的模式化肢体运动。在外周神经远端残端植入横断脊髓的情况下，该手术通过训练、调节以及化学和分子治疗增强了由中枢模式发生器（CPG）介导的功能。
