Turbes C C
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
Biomed Sci Instrum. 1997;33:326-31.
These studies involve 76 mature female dogs at 5.5 to 16 kg. The enhancement of axonal regeneration in the spinal cord transection is shown by implanting intercostal nerve with origin cephalic to spinal cord transection. The nerve is implanted in the distal isolated spinal cord near the transection site. The intercostal nerve peripheral portion is anchored in the distal spinal cord using a plasma clot suture. Regeneration of CNS axons and PNS axons in the spinal cord transection demands care, rehabilitation, and maintenance of normal body functions. After a period of two years repair and rehabilitation "reflex" standing and walking developed in 26 mature female dogs. Surgical section of the implanted nerve resulted in loss of standing and reflex walking and return to a paraplegic condition in 12 dogs. Stimulation of the motor cortex and implanted intercostal nerve resulted in movements of the hind limbs of the standing and reflex walking dogs all having cord transection and intercostal nerve anastomoses.
这些研究涉及76只体重在5.5至16千克的成年雌性犬。通过植入起源于脊髓横断上方的肋间神经，可显示脊髓横断处轴突再生的增强。该神经植入到靠近横断部位的远端孤立脊髓中。肋间神经外周部分使用血浆凝块缝线固定在远端脊髓中。脊髓横断处中枢神经系统轴突和外周神经系统轴突的再生需要护理、康复以及维持正常身体功能。经过两年的修复和康复，26只成年雌性犬出现了“反射性”站立和行走。对12只犬进行植入神经的手术切断后，它们失去了站立和反射性行走能力，恢复到截瘫状态。对站立和反射性行走的犬（均有脊髓横断和肋间神经吻合）的运动皮层和植入的肋间神经进行刺激，导致其后肢运动。
