Turbes C C
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
Biomed Sci Instrum. 1997;34:344-50.
The enhancement of axonal regeneration in the spinal cord transection is shown by implanting intercostal nerve neuroma with origin cephalic to spinal cord transection site. The nerve is implanted in the distal spinal cord near the transection site. The intercostal nerve peripheral portion is anchored in the distal spinal cord using a plasma clot suture. 2,3,4 Regeneration of (CNS) axons and (PNS) axons in the spinal cord transaction lesion demands care, rehabilitation, no infections, and maintenance of normal body functions. After a period of repair and rehabilitation "reflex" standing and walking developed in 26 mature female dogs. Surgical section of the implanted nerve resulted in loss of standing and reflex walking and return to a paraplegic condition. 2,3,4,5 Stimulation of the motor cortex and implanted intercostal nerve resulted in movements of the hind limbs of the standing and reflex walking dogs all having cord transection and intercostal nerve neuroma implantation. 2,3,4,5 The neuroma generates spontaneous electrical activity as unit discharges similar to seizure and epleptic activity. This activity has a role in spinal cord lesions in the induction of regeneration of axonal sprouting. 1,2,3,4,12,13,15
通过植入起源于脊髓横断部位头侧的肋间神经神经瘤，可显示脊髓横断处轴突再生的增强。将该神经植入靠近横断部位的脊髓远端。使用血浆凝块缝线将肋间神经外周部分固定在脊髓远端。中枢神经系统（CNS）轴突和外周神经系统（PNS）轴突在脊髓损伤部位的再生需要精心护理、康复、避免感染以及维持正常身体功能。经过一段时间的修复和康复，26只成年雌性犬出现了“反射性”站立和行走。切断植入的神经会导致站立和反射性行走能力丧失，重新回到截瘫状态。刺激运动皮层和植入的肋间神经会使所有患有脊髓横断和肋间神经神经瘤植入的站立和反射性行走犬的后肢产生运动。神经瘤会产生类似于癫痫发作和癫痫活动的单位放电形式的自发电活动。这种活动在脊髓损伤中对轴突发芽再生的诱导起作用。
