Chicherin Iu V, Evstigneev V I, Lebedinskiĭ V A, Vorob'ev A A, Zemskov E M
Zh Mikrobiol Epidemiol Immunobiol. 1979 Jun(6):67-71.
For the first time P. hamadryas were used for studying the effectiveness of oral immunization with dried live plague vaccine. Oral immunization was shown to produce morphological changes in the organs and tissues of the monkeys, which indicated the immune transformation of the organism. The challenge of the immunized animals with the infective agent introduced in aerosol showed the effectiveness of the inhalation and oral methods of immunization. P. hamadryas proved to be a suitable model for the evaluation of the effectiveness of oral vaccination. A more precise quantitative evaluation of the effectiveness of oral vaccination against plague requires further research.
首次使用阿拉伯狒狒研究冻干活鼠疫疫苗口服免疫的效果。口服免疫显示在猴子的器官和组织中产生形态学变化，这表明机体发生了免疫转化。用气溶胶形式引入感染因子对免疫动物进行攻击，显示出吸入和口服免疫方法的有效性。阿拉伯狒狒被证明是评估口服疫苗效果的合适模型。针对鼠疫口服疫苗效果进行更精确的定量评估需要进一步研究。
