Lebedinskiĭ V A, Chicherin Iu V, Evstigneev V I, Paramonov V E, Timofeev V V
Zh Mikrobiol Epidemiol Immunobiol. 1979 Sep(9):11-4.
The work deals with the results of the comparative evaluation of the effectiveness of vaccines developed at the Sanitary Research Institute (Zagorsk) and the Mechnikov Research Institute for Vaccines and Sera (Moscow), as well as two methods of immunization against plague, by inhalation and subcutaneous injection, under the conditions of aerosol infection. The immunogenic effectiveness of both vaccines, when evaluated in terms of LD50, was shown to be approximately the same, but the animals immunized by the inhalation method with the vaccine developed at the Sanitary Research Institute proved to be less susceptible to infection than those immunized with the vaccine developed at the Mechnikov Research Institute for Vaccines and Sera in Moscow. After immunization by the inhalation method the vaccine developed at the Sanitary Research Institute rendered more effective protection (3- to 4-fold) against aerosol infection than after immunization by subcutaneous injection. The animals immunized by the inhalation method proved to be capable of surviving plague in the primary pneumonic form.
该研究涉及对在卫生研究所（扎戈尔斯克）和梅契尼科夫疫苗与血清研究所（莫斯科）研发的疫苗有效性进行比较评估的结果，以及在气溶胶感染条件下通过吸入和皮下注射两种鼠疫免疫方法的效果。从半数致死剂量（LD50）角度评估，两种疫苗的免疫原性效力大致相同，但在卫生研究所研发的疫苗通过吸入法免疫的动物，相较于用莫斯科梅契尼科夫疫苗与血清研究所研发的疫苗免疫的动物，对感染的易感性更低。通过吸入法免疫后，卫生研究所研发的疫苗对气溶胶感染提供的保护作用（高3至4倍）比皮下注射免疫后更有效。通过吸入法免疫的动物被证明能够在原发性肺鼠疫形式下存活。
