[动物实验中口服鼠疫疫苗有效性的进一步研究]
[Further study of the effectiveness of oral immunization against plague in experiments on animals].
作者信息
Chicherin Iu V, Vorob'ev A A, Evstigneev V I, Lebedinskiĭ V A, Zemskov E M
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1979 Jan(1):102-4.
PMID:425749
Abstract
It was shown in comparative experiments on guinea pigs that the oral method of immunization with plague vaccine was much less effective than the inhalation and subcutaneous. Guinea pigs were found to be a poor model for studying the efficacy of oral immunization with dry live plague vaccine rehydrated before use: with the use of this preparation the animals were 46 times less resistant to aerosol plague infection than in application of strain EB cultured in agar.
摘要
在豚鼠身上进行的对比实验表明，用鼠疫疫苗进行口服免疫的方法比吸入法和皮下注射法的效果要差得多。研究发现，豚鼠并不是研究使用前重新水化的冻干活鼠疫疫苗口服免疫效果的理想模型：使用这种制剂时，动物对气溶胶鼠疫感染的抵抗力比使用在琼脂中培养的EB菌株时低46倍。
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