Chicherin Iu V, Evstigneev V I, Lebedinskiĭ V A
Zh Mikrobiol Epidemiol Immunobiol. 1977 May(5):95-8.
Experiments were conducted on guinea pigs and Papio hamadryas; it was shown that a reduction of the intensity of postvaccinal immunity occurred at various periods after a single vaccination. In inhalation method of immunization in guinea pigs it decreased in 6 months 135 times, in monkeys in one year--133 times. However, at the mentioned periods vaccination provided protection of 50% of the animals from infection with Past. pestis in a dose constitutin 20 to 25 aerosol LD50 for nonimmunized animals. Despite the more pronounced (57--640 times) reduction of the intensity of immunity than in the animals vaccinated by inhalation, in the subcutaneously vaccinated guinea pigs in subcutaneously infected with Past. pestis protection level remained high (resistance index in 3 and 6 months constituted 37.10(6) and 3-3-10(6), respectively).
在豚鼠和阿拉伯狒狒身上进行了实验；结果表明，单次接种疫苗后的不同时期，疫苗接种后免疫力强度会降低。在豚鼠的吸入免疫法中，6个月内免疫力降低了135倍，在猴子中1年内降低了133倍。然而，在上述时期，疫苗接种能使50%的动物免受鼠疫杆菌感染，对于未免疫动物而言，该剂量相当于20至25个气溶胶半数致死量。尽管皮下接种的豚鼠免疫力强度降低程度比吸入接种的动物更明显（57至640倍），但皮下感染鼠疫杆菌后，其保护水平仍然很高（3个月和6个月时的抗性指数分别为37.10(6)和3 - 3 - 10(6)）。
