Bonard D, Msellati P, Rigouts L, Combe P, Coulibaly D, Coulibaly I M, Portaels F
Centre de Diagnostic et de Recherche sur le SIDA et les Infections Opportunistes CHU de Treichville, Abidjan, C te d'Ivoire.
Int J Tuberc Lung Dis. 2000 Dec;4(12):1176-80.
Mycobacterium africanum is a member of the tuberculosis complex, together with M. tuberculosis and M. bovis. Its morphological growth is quite different from that of M tuberculosis. It is a causative agent of the same tuberculosis disease, and its precise identification seems important only for epidemiological purposes. We report here the repetitive isolation of 17 M. africanum strains (among 321 TB complex strains) during a national primary resistance survey in C te d'Ivoire in 1995. All of the M. africanum strains were isolated in four regions located in the same geographical area. They showed biochemical heterogeneity yielding three patterns, none of which was specific to one region. Molecular analysis by RFLP for 14 strains showed identical patterns for four strains, two by two, and a clustering of 62-77% homology for eight of the 14 strains (57%). This report confirms that M. africanum is less frequent than M. tuberculosis. Its repeated isolation may reflect inter-human transmission. Biochemical similarities between strains may not always be associated with a common geographical origin.
非洲分枝杆菌是结核分枝杆菌复合群的成员之一，与结核分枝杆菌和牛分枝杆菌同属该复合群。其形态生长与结核分枝杆菌有很大不同。它是同一种结核病的病原体，其精确鉴定似乎仅在流行病学方面具有重要意义。我们在此报告，在1995年科特迪瓦全国原发性耐药性调查期间（在321株结核分枝杆菌复合群菌株中）重复分离出17株非洲分枝杆菌菌株。所有非洲分枝杆菌菌株均在同一地理区域的四个地区分离得到。它们表现出生化异质性，产生三种模式，没有一种模式是某一地区特有的。对14株菌株进行的限制性片段长度多态性（RFLP）分子分析显示，有4株菌株两两之间呈现相同模式，14株菌株中的8株（57%）同源性聚类在62 - 77%。本报告证实，非洲分枝杆菌比结核分枝杆菌少见。其重复分离可能反映了人际传播。菌株之间的生化相似性可能并不总是与共同的地理来源相关。
