Rakover Y, Smuskovitz A, Colodner R, Keness Y, Rosen G
Department of Otorhinolaryngology, Ha'Emek Medical Center, Afula, Israel.
J Laryngol Otol. 2000 Nov;114(11):827-9. doi: 10.1258/0022215001904356.
The recommendation of Anderson and Steele, for the use of ear drops four times a day, has not been changed since 1948. In order to re-evaluate the frequency of using ear drops, we examined the duration of the effectiveness of the antibacterial activity of gentamicin ear drops in external otitis. Seventeen patients (25 ears) with external otitis were studied. We took 18 samples from each ear at 0, 1, 2, 3, 6, 8, 10, 12 and 14 hours and measured the concentration of gentamicin on the wick and in the ear canal. We found that the concentration of gentamicin began to decrease only after 12 hours and a more significant decrease was detected after 14 hours of treatment. We have shown that the antibiotic used on the wick is effective for 12 hours. In conclusion, we recommend using ear drops twice a day on a wick as routine therapy for external otitis.
自1948年以来，安德森和斯蒂尔提出的每天使用四次滴耳液的建议一直未变。为了重新评估滴耳液的使用频率，我们研究了庆大霉素滴耳液在外耳道炎中抗菌活性的有效持续时间。对17例（25只耳）外耳道炎患者进行了研究。我们在0、1、2、3、6、8、10、12和14小时从每只耳朵采集18个样本，测量药芯和耳道内庆大霉素的浓度。我们发现，庆大霉素浓度仅在12小时后开始下降，治疗14小时后下降更为明显。我们已经证明，药芯上使用的抗生素在12小时内有效。总之，我们建议将药芯上每天使用两次滴耳液作为外耳道炎的常规治疗方法。
