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疱疹病毒 4 型作为莱姆病性巩膜炎的启动子：系统文献回顾。

Epstein-Barr virus as promoter of Lemierre syndrome: systematic literature review.

机构信息

Family Medicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

出版信息

Eur Arch Otorhinolaryngol. 2024 Oct;281(10):5497-5502. doi: 10.1007/s00405-024-08767-x. Epub 2024 Jun 5.

DOI:10.1007/s00405-024-08767-x
PMID:38839700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11416426/
Abstract

PURPOSE

To investigate a possible link between acute Epstein-Barr virus infection and Lemierre syndrome, a rare yet life-threatening infection.

METHODS

A systematic review was conducted adhering to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnosis criteria for Lemierre syndrome were established, and data extraction encompassed demographic data, clinical, and laboratory information.

RESULTS

Out of 985 initially identified papers, 132 articles were selected for the final analysis. They reported on 151 cases of Lemierre syndrome (76 female and 75 male patients with a median of 18 years) alongside interpretable results for Epstein-Barr virus serology. Among these, 38 cases (25%) tested positive for acute Epstein-Barr virus serology. There were no differences in terms of age, sex, or Fusobacterium presence between the serologically positive and negative groups. Conversely, instances of cervical thrombophlebitis and pulmonary complications were significantly higher (P = 0.0001) among those testing negative. The disease course was lethal in one case for each of the two groups.

CONCLUSIONS

This analysis provides evidence of an association between acute Epstein-Barr virus infection and Lemierre syndrome. Raising awareness of this link within the medical community is desirable.

摘要

目的

探讨急性 EBV 感染与林氏综合征（一种罕见但危及生命的感染）之间可能存在的联系。

方法

本研究遵循 2020 年系统评价和荟萃分析报告的首选条目进行了系统综述。确立了林氏综合征的诊断标准，并对人口统计学数据、临床和实验室信息进行了数据提取。

结果

在最初确定的 985 篇论文中，有 132 篇文章被选入最终分析。这些文章共报道了 151 例林氏综合征（76 例女性和 75 例男性，中位数年龄为 18 岁），并对 EBV 血清学进行了可解释的结果分析。其中，38 例（25%）急性 EBV 血清学检测呈阳性。在年龄、性别或梭杆菌存在方面，血清学阳性和阴性组之间没有差异。相反，在 EBV 血清学检测阴性的患者中，颈静脉血栓性静脉炎和肺部并发症的发生率明显更高（P=0.0001）。两组各有一例患者的疾病过程是致命的。

结论

本分析提供了急性 EBV 感染与林氏综合征之间存在关联的证据。在医学界提高对这种联系的认识是可取的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8776/11416426/d13ff416c4ac/405_2024_8767_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8776/11416426/eea2ea5da533/405_2024_8767_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8776/11416426/d13ff416c4ac/405_2024_8767_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8776/11416426/eea2ea5da533/405_2024_8767_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8776/11416426/d13ff416c4ac/405_2024_8767_Fig2_HTML.jpg

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Influenza increases invasive meningococcal disease risk in temperate countries.流感会增加温带国家侵袭性脑膜炎球菌病的风险。
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