Cubilla A L, Meijer C J, Young R H
Instituto de Patologia e Investigacion, Facultad de Ciencias Medicas, Universidad Nacional de Asunción, Paraguay.
Scand J Urol Nephrol Suppl. 2000(205):215-9.
There is a heterogenous spectrum of abnormalities and atypical lesions in the penile epithelium. The terminology used to designate precursor lesions is variable but squamous intraepithelial lesions of low and high grade or penile intraepithelial neoplasia I, II and III are the recommended terms. Other probable precursor lesions are squamous hyperplasia and bowenoid papulosis. Low- and high-grade squamous intraepithelial lesions may be classified into squamous or simplex, the most frequent types, or warty (condylomatous) and basaloid. There is a striking morphological correspondence between precancerous lesions of the penis and their respective invasive lesions. The presence of two groups of lesions in the precancerous as well as invasive carcinomas, the squamous typical and the warty basaloid, is consistent with the bimodal hypothesis of the existence of non-HPV (the typical squamous) and HPV-related (warty or basaloid) tumors.
阴茎上皮存在多种异常和非典型病变。用于指定前驱病变的术语各不相同，但推荐使用低级别和高级别鳞状上皮内病变或阴茎上皮内瘤变I、II和III。其他可能的前驱病变是鳞状增生和鲍温样丘疹。低级别和高级别鳞状上皮内病变可分为鳞状或单纯型（最常见类型）、疣状（湿疣样）和基底样。阴茎癌前病变与其相应的浸润性病变之间存在显著的形态学对应关系。癌前病变以及浸润性癌中存在两组病变，即典型鳞状病变和疣状基底样病变，这与非HPV（典型鳞状）和HPV相关（疣状或基底样）肿瘤存在的双峰假说一致。
