Department of Dermatology, Hôpital Saint-Louis, Paris, France.
J Am Acad Dermatol. 2010 Feb;62(2):284-90. doi: 10.1016/j.jaad.2009.06.087.
In contrast to vulvar squamous cell carcinoma (SCC), the etiologic factors and precancerous lesions associated with penile carcinoma remain uncertain.
To describe the morphologic features of lesions adjacent to invasive penile SCC and their relationship with the associated carcinoma and to compare these associations with vulvar carcinoma.
This was a retrospective histologic analysis of 68 cases of penile SCC. Adjacent lesions were considered to be premalignant lesions. They were classified as penile intraepithelial neoplasia (PIN), squamous hyperplasia (SH), and lichen sclerosus (LS). PIN cases were divided into two subtypes depending on the extension of atypia throughout the epithelium and, by analogy, with the classification of the vulvar intraepithelial neoplasia (VIN). Thus they were designated as undifferentiated (or bowenoid) PIN, defined by full-thickness atypia throughout the epithelium, and differentiated PIN, characterized by atypia confined to the lower third of the epithelium. SCC subtypes were classified as usual, verrucous, warty (condylomatous), basaloid, and mixed.
Undifferentiated PIN was observed in 22 cases; LS was observed in 26 cases. Differentiated PIN and SH (except for two cases) were associated with underlying LS. Undifferentiated PIN was always associated with warty (condylomatous) (4 cases), basaloid (16 cases) or mixed SCC (2 cases), and LS with usual (19 cases) or verrucous SCC (7 cases).
This was a retrospective analysis
This study suggests that, similarly to vulvar carcinoma, penile SCC occurs in association with two types of penile lesions: undifferentiated (or bowenoid) PIN and LS-linked differentiated PIN and/or SH. It appears that the subtype of these carcinomas is related to these adjacent lesions.
与外阴鳞状细胞癌（SCC）不同，阴茎癌的病因和癌前病变尚不确定。
描述浸润性阴茎 SCC 相邻病变的形态学特征及其与相关癌的关系，并将这些关联与外阴癌进行比较。
这是对 68 例阴茎 SCC 的回顾性组织学分析。相邻病变被认为是癌前病变。它们分为阴茎上皮内瘤变（PIN）、鳞状增生（SH）和硬化性苔藓（LS）。PIN 病例根据上皮内不典型性的扩展程度分为两种亚型，并与外阴上皮内瘤变（VIN）的分类类似。因此，它们被指定为未分化（或鲍温样）PIN，定义为整个上皮层的全层不典型性，和分化型 PIN，其特征为仅局限于上皮下三分之一的不典型性。SCC 亚型分为普通型、疣状型、湿疣（湿疣样）型、基底细胞样型和混合型。
观察到 22 例未分化 PIN；26 例 LS。分化型 PIN 和 SH（除了两例外）与潜在的 LS 相关。未分化的 PIN 总是与湿疣（湿疣样）（4 例）、基底细胞样（16 例）或混合 SCC（2 例）相关，LS 与普通型（19 例）或疣状 SCC（7 例）相关。
这是一项回顾性分析。
本研究表明，与外阴癌类似，阴茎 SCC 发生于两种类型的阴茎病变：未分化（或鲍温样）PIN 和 LS 相关的分化型 PIN 和/或 SH。这些癌的亚型似乎与这些相邻病变有关。
