Tarumi H, Imazato S, Narimatsu M, Matsuo M, Ebisu S
Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
J Dent Res. 2000 Nov;79(11):1838-43. doi: 10.1177/00220345000790110401.
It is controversial whether the dental resinous materials containing 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl]propane (Bis-GMA), which is synthesized from the estrogenic compound bisphenol A (BPA), include unreacted BPA and/or can mimic the effects of natural steroid hormones. In the present study, the estrogenic activities of 3 fissure sealants and 5 adhesive resins, which were all unpolymerized, were determined by means of a reporter gene assay, and the relevance of the components to the estrogenicity was investigated. Two commercially available sealants were confirmed to have estrogenic activity, although none of the tested materials contained BPA. In contrast, hydrophobic monomer bisphenol A dimethacrylate (BPA-DMA), which is also estrogenic, was found to be included in these estrogenic sealants in an amount greater than the minimum concentration to show estrogenicity. This suggests that the estrogenicity of the two proprietary sealants was associated with BPA-DMA rather than with BPA.
由雌激素化合物双酚A（BPA）合成的含2,2-双[4-(2-羟基-3-甲基丙烯酰氧基丙氧基)苯基]丙烷（Bis-GMA）的牙科树脂材料是否含有未反应的BPA和/或是否能模拟天然甾体激素的作用，这存在争议。在本研究中，通过报告基因检测法测定了3种窝沟封闭剂和5种未聚合的粘结树脂的雌激素活性，并研究了各成分与雌激素性的相关性。尽管所测试的材料均不含BPA，但证实两种市售封闭剂具有雌激素活性。相反，具有雌激素性的疏水单体双酚A二甲基丙烯酸酯（BPA-DMA）被发现存在于这些具有雌激素活性的封闭剂中，其含量高于显示雌激素性的最低浓度。这表明这两种专利封闭剂的雌激素性与BPA-DMA有关，而非与BPA有关。
