Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School/Massachusetts General Hospital Fertility Center, Yawkey 10-A, 55 Fruit Street, Boston, MA 02114, USA.
Reprod Toxicol. 2013 Dec;42:224-31. doi: 10.1016/j.reprotox.2013.09.008. Epub 2013 Oct 4.
In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (±GSD) of 1.6±2.0, 1.7±2.1, and 1.5±1.8μg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
在这项对接受不孕治疗的女性进行的前瞻性队列研究中,我们测量了比重调整后的尿液 BPA(SG-BPA)浓度,并使用回归模型评估了 BPA 与窦卵泡计数(AFC)、第 3 天血清卵泡刺激素水平(FSH)和卵巢体积(OV)之间的关系。在 >80%的女性中检测到 BPA,在参与 AFC(n=154)、第 3 天 FSH(n=120)和 OV(n=114)分析的女性中,BPA 的几何平均值(±GSD)分别为 1.6±2.0、1.7±2.1 和 1.5±1.8μg/L。与第 1 四分位相比,第 2、3 和 4 四分位的 AFC 分别平均降低了 12%(95%CI:-23%,-0.6%)、22%(95%CI:-31%,-11%)和 17%(95%CI:-27%,-6%)(p 趋势:<0.001)。未观察到 SG-BPA 与 FSH 或 OV 之间存在关联。在不孕诊所的女性中,较高的尿液 BPA 浓度与 AFC 较低有关,这引发了对可能加速卵泡损失和生殖衰老的担忧。