Hulthe J, Bokemark L, Fagerberg B
Wallenberg Laboratory for Cardiovascular Research, Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden.
Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):101-7. doi: 10.1161/01.atv.21.1.101.
Antibody (Ab) titers to oxidized low density lipoprotein (OxLDL) have been found to be independent predictors of the progression of carotid atherosclerosis. Ab titers against OxLDL may be related to the entire burden of atherosclerosis in the vascular tree or, more specifically, to the disease process in different arterial regions. Therefore, the aim of the present study was to investigate the relationship between IgG and IgM titers to modified LDL and intima-media thickness (IMT) in the carotid and femoral arteries in subjectively clinically healthy 58-year-old men. IMT was measured by ultrasound, and Ab titers to modified LDL were measured by ELISA. The results showed that the common carotid artery IMT was associated with elevated titers of IgG-OxLDL Ab and independently with systolic blood pressure, smoking, and body mass index. The femoral artery IMT showed a negative correlation to IgM-OxLDL Ab and independent associations with smoking, systolic blood pressure, and total cholesterol. To summarize, in 58-year-old subjectively clinically healthy men recruited from the general population, there was a positive association between IgG-OxLDL Ab and IMT in the common carotid artery and a negative association between IgM-OxLDL Ab and IMT in the common femoral artery. However, these associations were not independent of other risk factors.
已发现氧化型低密度脂蛋白（OxLDL）的抗体（Ab）滴度是颈动脉粥样硬化进展的独立预测指标。针对OxLDL的Ab滴度可能与血管树中动脉粥样硬化的整体负担有关，或者更具体地说，与不同动脉区域的疾病进程有关。因此，本研究的目的是调查主观临床健康的58岁男性中，针对修饰型LDL的IgG和IgM滴度与颈动脉和股动脉内膜中层厚度（IMT）之间的关系。通过超声测量IMT，通过酶联免疫吸附测定法（ELISA）测量针对修饰型LDL的Ab滴度。结果显示，颈总动脉IMT与IgG-OxLDL Ab滴度升高相关，且独立于收缩压、吸烟和体重指数。股动脉IMT与IgM-OxLDL Ab呈负相关，并与吸烟、收缩压和总胆固醇独立相关。总之，在从普通人群中招募的主观临床健康的58岁男性中，颈总动脉中IgG-OxLDL Ab与IMT呈正相关，股总动脉中IgM-OxLDL Ab与IMT呈负相关。然而，这些关联并非独立于其他危险因素。
