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[弓形虫病血清学诊断中特异性免疫球蛋白G亲和力的测定]

[Determination of specific immunoglobin G avidity in serodiagnosis of toxoplasmosis].

作者信息

Bitkowska E, Waloch M, Dzbeński T H

机构信息

Zakład Parazytologii Lekarskiej PZH w Warszawie.

出版信息

Med Dosw Mikrobiol. 2000;52(3):295-300.

PMID:11147271
Abstract

A total of 37 serum samples from pregnant women were examined for the avidity of toxoplasma IgG antibodies using commercially available enzyme immunoassay (Vidas Toxo IgG Avidity, bio Merieux). Low values of the avidity index were found for 4 samples and borderline ones were found in further 3 cases. Out of 19 serum samples showing the presence of IgG and IgM toxoplasma antibodies, 13 had high avidity index, including 9 samples from women in the first trimester of pregnancy. The results of examinations in these 9 cases allowed to exclude the possibility that toxoplasma infection was acquired during gestation. It is to be concluded that determinations of antitoxoplasma IgG avidity should become routine in every pregnant woman positive in the test for specific IgM antibody.

摘要

使用市售酶免疫测定法(Vidas Toxo IgG 亲和力检测试剂盒,生物梅里埃公司)对 37 名孕妇的血清样本进行了弓形虫 IgG 抗体亲和力检测。4 份样本的亲和力指数值较低,另有 3 例处于临界值。在 19 份显示存在弓形虫 IgG 和 IgM 抗体的血清样本中,13 份具有高亲和力指数,其中包括 9 份来自妊娠早期女性的样本。这 9 例的检测结果排除了妊娠期感染弓形虫的可能性。可以得出结论,对于特异性 IgM 抗体检测呈阳性的每位孕妇,抗弓形虫 IgG 亲和力测定应成为常规检查。

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