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[弓形虫IgG亲和力检测在孕妇血清学监测中的相关性]

[Relevance of the toxoplasma IgG avidity test in the serological surveillance of pregnant women].

作者信息

Soula F, Fréalle E, Durand-Joly I, Dutoit E, Rouland V, Renard E, Houfflin-Debarge V, Subtil D, Camus D, Dei-Cas E, Delhaes L

机构信息

Service de parasitologie-mycologie, CHRU de Lille - Faculté de Médecine, Université de Lille 2, and Clinique de gynécologie et obstétrique, Hôpital Jeanne de Flandre, France.

出版信息

Ann Biol Clin (Paris). 2007 May-Jun;65(3):257-64.

Abstract

In addition to the serological systematic screening tests, kits to measure the avidity of toxoplasma IgG antibodies are currently available. Since high-avidity IgG toxoplasma antibodies have been shown to exclude recent infection, IgG avidity determination is especially useful in ruling out acute infection having occurred in the 3-4 prior months of pregnancy. We therefore compared the efficacy of two toxoplasma IgG avidity ELISA kits: SFRI (SFRI Laboratoire) and VIDAS Toxo-IgG avidity kit (bioMérieux). The agreement of the results from the 2 commercial assays were analysed using 55 serum samples, in terms of global mother-child Toxoplasma results and outcome, specially with light of the results of Toxoplasma antenatal, postnatal assays and of clinical follow up of children.

摘要

除了血清学系统筛查试验外,目前已有检测弓形虫IgG抗体亲和力的试剂盒。由于高亲和力IgG弓形虫抗体已被证明可排除近期感染,因此IgG亲和力测定对于排除妊娠前3至4个月内发生的急性感染特别有用。因此,我们比较了两种弓形虫IgG亲和力ELISA试剂盒的效果:SFRI(SFRI Laboratoire公司)和VIDAS弓形虫IgG亲和力试剂盒(生物梅里埃公司)。使用55份血清样本,根据母婴弓形虫检测的总体结果和结局,特别是结合弓形虫产前、产后检测结果以及儿童临床随访结果,分析了这两种商业检测方法结果的一致性。

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