异基因骨髓移植相关的I型人类嗜T淋巴细胞病毒（HTLV-I）传播。

Allogeneic bone marrow transplantation-related transmission of human T lymphotropic virus type I (HTLV-I).

作者信息

Kikuchi H, Ohtsuka E, Ono K, Nakayama T, Saburi Y, Tezono K, Ogata M, Iwahashi M, Nasu M

机构信息

Second Department of Internal Medicine, Oita Medical University, Hasama-Oita, Japan.

出版信息

Bone Marrow Transplant. 2000 Dec;26(11):1235-7. doi: 10.1038/sj.bmt.1702698.

DOI:10.1038/sj.bmt.1702698

PMID:11149739

Abstract

We report here the first case report of bone marrow transplantation (BMT)-related transmission of human T lymphotropic virus type-I (HTLV-I). Antibodies against HTLV-I-associated antigens (anti-HTLV-I) were detected in the serum from the BMT recipient 12 days post BMT. IgG against gag core proteins (anti-p19 and anti-p24) appeared earlier than IgM against gag and env proteins (anti-p19, anti-p24 and anti-gp46) during seroconversion. The data presented here differs from blood transfusion-related seroconversion. This phenomenon may be due to the engraftment of anti-HTLV-I producing cells from the donor.

摘要

我们在此报告首例与骨髓移植（BMT）相关的人类I型嗜T淋巴细胞病毒（HTLV-I）传播病例。在骨髓移植受者骨髓移植后12天的血清中检测到针对HTLV-I相关抗原的抗体（抗HTLV-I）。在血清转化过程中，针对gag核心蛋白的IgG（抗p19和抗p24）比针对gag和env蛋白的IgM（抗p19、抗p24和抗gp46）出现得更早。此处呈现的数据与输血相关的血清转化不同。这种现象可能是由于供体中产生抗HTLV-I的细胞植入所致。