Allogeneic bone marrow transplantation-related transmission of human T lymphotropic virus type I (HTLV-I).

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作者信息

Kikuchi H, Ohtsuka E, Ono K, Nakayama T, Saburi Y, Tezono K, Ogata M, Iwahashi M, Nasu M

机构信息

Second Department of Internal Medicine, Oita Medical University, Hasama-Oita, Japan.

出版信息

Bone Marrow Transplant. 2000 Dec;26(11):1235-7. doi: 10.1038/sj.bmt.1702698.

DOI:10.1038/sj.bmt.1702698

PMID:11149739

Abstract

We report here the first case report of bone marrow transplantation (BMT)-related transmission of human T lymphotropic virus type-I (HTLV-I). Antibodies against HTLV-I-associated antigens (anti-HTLV-I) were detected in the serum from the BMT recipient 12 days post BMT. IgG against gag core proteins (anti-p19 and anti-p24) appeared earlier than IgM against gag and env proteins (anti-p19, anti-p24 and anti-gp46) during seroconversion. The data presented here differs from blood transfusion-related seroconversion. This phenomenon may be due to the engraftment of anti-HTLV-I producing cells from the donor.

摘要