MK-801、丹曲林和FK506对癫痫易感EL小鼠惊厥性癫痫发作及脑内一氧化氮生成的影响
Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.
作者信息
Nagatomo I, Hashiguchi W, Tominaga M, Akasaki Y, Uchida M, Takigawa M
机构信息
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, 890-8520, Kagoshima, Japan.
出版信息
Brain Res. 2001 Jan 12;888(2):306-310. doi: 10.1016/s0006-8993(00)03101-2.
To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx). MK-801 or dantrolene, but not FK506, suppressed convulsive seizures in EL mice; only MK-801 reduced NOx in the brain. Our results suggested involvement of the N-methyl-D-aspartate receptor-channel complex and intracellular calcium mobilization, but not calcineurin, in the convulsions of EL mice.
为阐明一氧化氮（NO）在易患癫痫的EL小鼠癫痫发病机制中的作用，我们研究了三种可能与NO生成相关的药物，即MK-801、丹曲林和FK506，对惊厥性癫痫发作和脑内NO代谢产物（NOx）的影响。MK-801或丹曲林可抑制EL小鼠的惊厥性癫痫发作，但FK506无此作用；只有MK-801可降低脑内NOx水平。我们的结果表明，N-甲基-D-天冬氨酸受体通道复合物和细胞内钙动员参与了EL小鼠的惊厥发作，而钙调神经磷酸酶未参与其中。
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