Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 33-35, 71 000 Sarajevo, Bosnia-Herzegovina.
J Neural Transm (Vienna). 2012 Jan;119(1):7-11. doi: 10.1007/s00702-011-0686-6. Epub 2011 Jul 21.
Nitric oxide (NO), a neurotransmitter and a free radical, has been purported to be involved in numerous neurological diseases. We investigated the serum nitric oxide concentration in 30 patients with multiple sclerosis (MS), in 30 patients with epilepsy and in 30 control subjects. The aim was also to determine whether a statistically significant difference in serum NO concentrations exists between the groups of interest. The total serum nitric oxide concentration was measured using the Griess reaction after reducing nitrates to nitrites with elemental zinc. In the group multiple sclerosis, the mean NO concentrations were X ± SEM = 31.02 ± 1.79 μmol/l, in the control group X ± SEM = 25.31 ± 1.44 μmol/l and in the group epilepsy X ± SEM = 22.51 ± 1.28 μmol/l. Student's t test showed a statistically significant difference between subjects with multiple sclerosis and the control group (p = 0.013), as well as between the groups multiple sclerosis and epilepsy (p = 0.0002). This data confirms that NO may play an important role in the pathogenesis of multiple sclerosis, whereas its role in epilepsy still remains unclear.
一氧化氮（NO）作为一种神经递质和自由基，据称与许多神经系统疾病有关。我们研究了 30 例多发性硬化症（MS）患者、30 例癫痫患者和 30 名对照组患者的血清一氧化氮浓度。目的还在于确定感兴趣的组之间的血清 NO 浓度是否存在统计学上的显著差异。使用元素锌将硝酸盐还原为亚硝酸盐后，通过格里塞反应测量总血清一氧化氮浓度。在多发性硬化症组中，NO 浓度的平均值为 X ± SEM = 31.02 ± 1.79 μmol/L，在对照组中为 X ± SEM = 25.31 ± 1.44 μmol/L，在癫痫组中为 X ± SEM = 22.51 ± 1.28 μmol/L。学生 t 检验显示多发性硬化症患者与对照组之间（p = 0.013）以及多发性硬化症组和癫痫组之间（p = 0.0002）存在统计学上的显著差异。该数据证实，NO 可能在多发性硬化症的发病机制中起重要作用，而其在癫痫中的作用仍不清楚。
