Albert W
Folia Histochem Cytochem (Krakow). 1976;14(3):181-7.
Close correlation between the size of Morris hepatoma 5123D implanted in the hind limb of rat and serum gamm-glutamyltranspeptidase activity was found. The tumour implanted in both hind legs of the rat resulted in about twofold increase of the serum enzyme activity. The growth of the hepatoma resulted also in a significant increase in the enzyme activity in urine of the tumour-bearing rats. After surgical removal of the leg with hepatoma a rapid decrease in the enzyme activity in both the studied body fluids and its subsequent renewed increase associated with formation of pulmonary metastases were observed. Partial hepatectomy and pancreatectomy were without effect on the serum gamma-glutamyltranspeptidase activity.
研究发现，植入大鼠后肢的莫里斯5123D肝癌大小与血清γ-谷氨酰转肽酶活性密切相关。将肿瘤植入大鼠的两条后肢会导致血清酶活性增加约两倍。肝癌的生长还导致荷瘤大鼠尿液中的酶活性显著增加。手术切除患肝癌的腿部后，观察到所研究的两种体液中的酶活性迅速下降，随后又随着肺转移灶的形成而再次升高。部分肝切除术和胰腺切除术对血清γ-谷氨酰转肽酶活性没有影响。
