莫氏肝癌5123D在F1（布法罗大鼠×威斯塔大鼠）大鼠体内传代对γ-谷氨酰转肽酶活性永久性降低的影响。

Effect of passages of Morris hepatoma 5123D in F1 (Buffalo X Wistar) rats on permanent decrease of gamma-glutamyltranspeptidase activity.

作者信息

Albert Z, Szewczuk A, Albert W

出版信息

Neoplasma. 1977;24(1):49-55.

Abstract

The Morris hepatoma 5123D after at least two passages in F1 (Buffalo X Wistar) rats shows quicker growth than the original tumor and bearers of it have much lower gamma-glutamyltranspeptidase activity in serum, urine, tumor and in some other organs. This new variant of the hepatoma was labeled as hepatoma 5123D/AS. Simultaneous implantation of hepatomas 5123D/AS and 5123D in the same rats prevents the increase of serum gamma-glutamyltranspeptidase activity. After surgical removal of the former tumor, the enzyme activity in serum quickly increases. No significant differences in some other peptidase activities were observed between the variant and hepatoma 5123D.

摘要

在F1（布法罗大鼠×Wistar大鼠）大鼠中至少传代两次后的莫里斯肝癌5123D，其生长速度比原始肿瘤更快，并且其携带者血清、尿液、肿瘤及其他一些器官中的γ-谷氨酰转肽酶活性要低得多。这种肝癌的新变种被标记为肝癌5123D/AS。在同一只大鼠中同时植入肝癌5123D/AS和5123D可防止血清γ-谷氨酰转肽酶活性升高。手术切除前一种肿瘤后，血清中的酶活性迅速增加。该变种与肝癌5123D在其他一些肽酶活性方面未观察到显著差异。