在布法罗大鼠以及F1（布法罗大鼠×威斯塔大鼠）大鼠中传代的莫氏肝癌5123D中的γ-谷氨酰转移酶
Gamma-glutamyltransferase in Morris hepatomas 5123D passaged in Buffalo and in F1 (Buffalo x Wistar) rats.
作者信息
Szewczuk A, Milnerowicz H, Albert Z, Richter R
出版信息
Neoplasma. 1980;27(3):241-5.
PMID:6109259
Abstract
Comparative biochemical and immunological investigations were performed on purified gamma-glutamyltransferase from the Morris hepatoma 5123D and from the 5123D/AS variant passaged in F1 (Buffalo x Wistar) rats. The enzyme was also localized in hepatoma sections by immunofluorescent technique. The obtained results confirm the hypothesis that low gamma-glutamyltransferase activity in Morris hepatoma 5123D/AS is caused by the enzymatic protein defficiency and not by the inhibition of the enzyme.
摘要
对从莫里斯肝癌5123D以及在F1（布法罗大鼠×威斯塔大鼠）大鼠中传代的5123D/AS变体中纯化得到的γ-谷氨酰转移酶进行了比较生化和免疫学研究。还通过免疫荧光技术将该酶定位在肝癌切片中。所得结果证实了以下假设：莫里斯肝癌5123D/AS中γ-谷氨酰转移酶活性低是由酶蛋白缺乏引起的，而非酶的抑制作用所致。
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