野生型昼夜节律依赖于果蝇无时间基因启动子中紧密间隔的E盒。
Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter.
作者信息
McDonald M J, Rosbash M, Emery P
机构信息
Department of Biology, National Science Foundation Center for Biological Timing, Waltham, Massachusetts 02454, USA.
出版信息
Mol Cell Biol. 2001 Feb;21(4):1207-17. doi: 10.1128/MCB.21.4.1207-1217.2001.
Abstract
Transcriptional regulation plays an important role in Drosophila melanogaster circadian rhythms. The period promoter has been well studied, but the timeless promoter has not been analyzed in detail. Mutagenesis of the canonical E box in the timeless promoter reduces but does not eliminate timeless mRNA cycling or locomotor activity rhythms. This is because there are at least two other cis-acting elements close to the canonical E box, which can also be transactivated by the circadian transcription factor dCLOCK. These E-box-like sequences cooperate with the canonical E-box element to promote high-amplitude transcription, which is necessary for wild-type rhythmicity.
摘要
转录调控在黑腹果蝇的昼夜节律中起着重要作用。周期基因启动子已得到充分研究，但无时间基因启动子尚未得到详细分析。无时间基因启动子中典型E框的诱变会降低但不会消除无时间基因mRNA的循环或运动活动节律。这是因为在典型E框附近至少还有另外两个顺式作用元件，它们也可以被昼夜节律转录因子dCLOCK反式激活。这些类E框序列与典型E框元件协同作用，以促进高振幅转录，这对于野生型节律性是必需的。
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