• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

8-喹啉醇及其铜(II)双螯合物的杀真菌毒性逆转。I. 氨基酸及相关化合物。

Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.

作者信息

Gershon H, Parmegiani R, Hauck J B

出版信息

Can J Microbiol. 1975 Mar;21(3):409-11. doi: 10.1139/m75-056.

DOI:10.1139/m75-056
PMID:1116048
Abstract

The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper (II) bischelates to Aspergillus oryzae (ATCC 1011) Was studied. None of the compounds tested except the thiol-containing compounds, cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis (8-quinolinolato) copper (II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato) copper (II.).

摘要

研究了氨基酸及相关化合物对8-喹啉醇及其铜(II)双螯合物对米曲霉(ATCC 1011)毒性的影响。除含硫醇化合物(半胱氨酸、半胱胺、谷胱甘肽和N-乙酰半胱氨酸)外,所测试的化合物均不能逆转8-喹啉醇的抑制作用,但不能逆转5-碘-8-喹啉醇或双(8-喹啉醇基)铜(II)的抑制作用。看来8-喹啉醇的杀真菌毒性机制与5-碘-8-喹啉醇或双(8-喹啉醇基)铜(II)的机制不同。

相似文献

1
Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.8-喹啉醇及其铜(II)双螯合物的杀真菌毒性逆转。I. 氨基酸及相关化合物。
Can J Microbiol. 1975 Mar;21(3):409-11. doi: 10.1139/m75-056.
2
Reversal of fungitoxicity of 8-quinolinols and their copper(II) bischelates. II. Reversal of the action of 8-quinolinol by DL-alpha-lipoic acid.
Can J Microbiol. 1981 Jun;27(6):612-26. doi: 10.1139/m81-093.
3
Evidence that the mechanisms of fungitoxicity of 8-quinolinol and its bischelate with copper(II) are different.8-喹啉醇及其与铜(II)的双螯合物的杀真菌毒性机制不同的证据。
Can J Microbiol. 1985 Aug;31(8):707-10. doi: 10.1139/m85-134.
4
Synergistic antifungal action of 8-quinolinol and its bischelate with copper(II) and with mixed ligand chelates composed of copper(II), 8-quinolinol, and aromatic hydroxy acids.8-喹啉醇及其与铜(II)的双螯合物以及由铜(II)、8-喹啉醇和芳香族羟基酸组成的混合配体螯合物的协同抗真菌作用。
J Pharm Sci. 1989 Nov;78(11):975-8. doi: 10.1002/jps.2600781120.
5
Evidence of steric factors in the fungitoxic mechanisms of 8-quinolinol and its 5- and 7-halogenated analogues.
J Pharm Sci. 1991 Jun;80(6):542-4. doi: 10.1002/jps.2600800608.
6
Antifungal activity of bischelates of 5-,7-, and 5,7-halogenated 8-quinolinols with copper(II). Determination of approximate dimensions of the long and short axes of the pores in the fungal spore wall.5-、7-和5,7-卤代8-喹啉醇与铜(II)的双螯合物的抗真菌活性。真菌孢子壁中孔的长轴和短轴近似尺寸的测定。
J Med Chem. 1974 Aug;17(8):824-7. doi: 10.1021/jm00254a009.
7
Antifungal activity of 5-, 7-, and 5,7-substituted 2-methyl-8-quinolinols.5-、7-以及5,7-取代的2-甲基-8-喹啉醇的抗真菌活性
Antimicrob Agents Chemother. 1972 May;1(5):373-5. doi: 10.1128/AAC.1.5.373.
8
Synergistic mixtures of fungitoxic monochloro and dichloro-8-quinolinols against five fungi.
Mycopathologia. 2004 Jul;158(1):131-5. doi: 10.1023/b:myco.0000038427.42852.6a.
9
Antifungal activity of substituted 8-quinolinol-5- and 7-sulfonic acids: a mechanism of action is suggested based on intramolecular synergism.取代的8-喹啉醇-5-磺酸和7-磺酸的抗真菌活性:基于分子内协同作用提出作用机制。
Mycopathologia. 2002;155(4):213-7. doi: 10.1023/a:1021166500169.
10
The effects of amino acids and metals on the infectivity of poliovirus ribonucleic acid.氨基酸和金属对脊髓灰质炎病毒核糖核酸感染性的影响。
Jpn J Microbiol. 1974 Mar;18(2):107-12. doi: 10.1111/j.1348-0421.1974.tb00797.x.

引用本文的文献

1
Synergistic mixtures of fungitoxic monochloro and dichloro-8-quinolinols against five fungi.
Mycopathologia. 2004 Jul;158(1):131-5. doi: 10.1023/b:myco.0000038427.42852.6a.