Gershon H, Parmegiani R, Hauck J B
Can J Microbiol. 1975 Mar;21(3):409-11. doi: 10.1139/m75-056.
The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper (II) bischelates to Aspergillus oryzae (ATCC 1011) Was studied. None of the compounds tested except the thiol-containing compounds, cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis (8-quinolinolato) copper (II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato) copper (II.).
研究了氨基酸及相关化合物对8-喹啉醇及其铜(II)双螯合物对米曲霉(ATCC 1011)毒性的影响。除含硫醇化合物(半胱氨酸、半胱胺、谷胱甘肽和N-乙酰半胱氨酸)外,所测试的化合物均不能逆转8-喹啉醇的抑制作用,但不能逆转5-碘-8-喹啉醇或双(8-喹啉醇基)铜(II)的抑制作用。看来8-喹啉醇的杀真菌毒性机制与5-碘-8-喹啉醇或双(8-喹啉醇基)铜(II)的机制不同。