Gershon H, Parmegiani R, Godfrey P K
Antimicrob Agents Chemother. 1972 May;1(5):373-5. doi: 10.1128/AAC.1.5.373.
2-Methyl-8-quinolinol and sixteen 5-, 7-, and 5,7-substituted derivatives with fluoro, chloro, bromo, iodo, nitro, and amino substituents were tested for in vitro antifungal activity against five fungi, Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes. The 5,7-dichloro and 5,7-dibromo derivatives were the most fungitoxic of the compounds tested. With the exception of these two compounds and 5-iodo-2-methyl-8-quinolinol, the 2-methyl analogues were less active than the corresponding 8-quinolinols.
对2-甲基-8-喹啉醇以及16种带有氟、氯、溴、碘、硝基和氨基取代基的5-、7-和5,7-取代衍生物进行了体外抗真菌活性测试，测试对象为5种真菌，即黑曲霉、米曲霉、绿色木霉、疣孢漆斑菌和须癣毛癣菌。5,7-二氯和5,7-二溴衍生物是所测试化合物中真菌毒性最强的。除了这两种化合物以及5-碘-2-甲基-8-喹啉醇外，2-甲基类似物的活性低于相应的8-喹啉醇。
