Gershon H, Clarke D D, Gershon M
Fordham University, Department of Chemistry, Bronx, NY 10458.
J Pharm Sci. 1989 Nov;78(11):975-8. doi: 10.1002/jps.2600781120.
Antifungal studies were made of mixtures of minimal inhibitory concentrations (MICs) of 8-quinolinol and its bischelates with copper(II), zinc(II), and manganese(II) and with mixed ligand chelates composed of 8-quinolinol, copper(II) and a second ligand including salicylic acid, 3-hydroxy-2-naphthoic acid, 3,5-diiodosalicylic acid, and 4-bromo-3-hydroxy-2-naphthoic acid. Mixtures of the MICs of the bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II), as well as 7-iodo-8-quinolinol and its bischelate with copper(II), and 8-quinolinol and 5-iodo-8-quinolinol were also studied against six fungi: Aspergillus niger, Aspergillus oryzae, Trichoderma viride, Myrothecium verrucaria, Mucor cirinelloides, and Trichophyton mentagrophytes. With the exceptions of the mixtures of 8-quinolinol and (8-quinolinolato)(3,5-diiodosalicylato)copper(II) and (8-quinolinolato)(4-bromo-3-hydroxy-2-naphthoato)copper(II) against M. cirinelloides, all of the test organisms were inhibited by 40% or less of each mixture containing 8-quinolinol. Bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II) inhibited five fungi at 50% of the mixtures of the MICs. Mucor cirinelloides was not inhibited by bis(8-quinolinolato)copper(II), bis(8-quinolinolato)zinc(II), or by bis(7-iodo-8-quinolinolato)copper(II).(ABSTRACT TRUNCATED AT 250 WORDS)
对8-喹啉醇及其与铜（II）、锌（II）和锰（II）的双螯合物以及由8-喹啉醇、铜（II）和包括水杨酸、3-羟基-2-萘甲酸、3,5-二碘水杨酸和4-溴-3-羟基-2-萘甲酸的第二种配体组成的混合配体螯合物的最低抑菌浓度（MIC）混合物进行了抗真菌研究。还研究了8-喹啉醇与铜（II）和锌（II）以及铜（II）和锰（II）的双螯合物的MIC混合物，以及7-碘-8-喹啉醇及其与铜（II）的双螯合物，和8-喹啉醇与5-碘-8-喹啉醇对六种真菌的作用：黑曲霉、米曲霉、绿色木霉、疣孢漆斑菌、卷枝毛霉和须癣毛癣菌。除了8-喹啉醇与（8-喹啉醇根）（3,5-二碘水杨酸根）铜（II）和（8-喹啉醇根）（4-溴-3-羟基-2-萘甲酸根）铜（II）对卷枝毛霉的混合物外，所有受试生物均被含8-喹啉醇的每种混合物抑制40%或更低。8-喹啉醇与铜（II）和锌（II）以及铜（II）和锰（II）的双螯合物在MIC混合物的50%时抑制了五种真菌。卷枝毛霉未被双（8-喹啉醇根）铜（II）、双（8-喹啉醇根）锌（II）或双（7-碘-8-喹啉醇根）铜（II）抑制。（摘要截断于250字）
