卡波西肉瘤相关疱疹病毒：一种新型DNA肿瘤病毒。

Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus.

作者信息

Boshoff C, Chang Y

机构信息

The CRC Viral Oncology Group, Department of Oncology, Sir Jules Thorn Institute, University College London, London W1N 8AA, United Kingdom.

出版信息

Annu Rev Med. 2001;52:453-70. doi: 10.1146/annurev.med.52.1.453.

DOI:10.1146/annurev.med.52.1.453

PMID:11160789

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a newly identified gammaherpesvirus associated with all clinical forms of Kaposi's sarcoma (KS), body-cavity-based, primary effusion lymphomas (PELs), and a subset of Castleman's disease (CD). Sequence analysis of the KSHV genome demonstrates an extensive array of genes with homology to cellular genes involved in cell cycle regulation, cell proliferation, apoptosis, and immune modulation. Functional studies indicate that these genes may modify the host cell environment, contributing to the pathogenesis of KSHV-associated disorders. Several KSHV genes have been found to cause dysregulated cell proliferation or to interfere with established tumor suppressor pathways. The epidemiologic association of KSHV with malignancies and the coding features of its genome suggest that it is a new DNA tumor virus.

摘要

卡波西肉瘤相关疱疹病毒（KSHV）是一种新发现的γ疱疹病毒，与卡波西肉瘤（KS）的所有临床形式、体腔型原发性渗出性淋巴瘤（PEL）以及一部分卡斯特曼病（CD）相关。对KSHV基因组的序列分析表明，它有大量与参与细胞周期调控、细胞增殖、凋亡和免疫调节的细胞基因具有同源性的基因。功能研究表明，这些基因可能会改变宿主细胞环境，从而导致与KSHV相关疾病的发病机制。已发现几种KSHV基因可导致细胞增殖失调或干扰既定的肿瘤抑制途径。KSHV与恶性肿瘤的流行病学关联及其基因组的编码特征表明它是一种新的DNA肿瘤病毒。