Peters J L, Volder J, Kessler T, Wood J, Kolff W J
Chest. 1975 Feb;67(2):199-206. doi: 10.1378/chest.67.2.199.
Improved technology in artificial heart development and implantation studies in unanesthetized calves have stimulated a new model for cardiovascular research. Independent control of the left and right ventricles, replacement of the natural right atrium with an artificial atrium (with a compliant inner diaphragm) are illustrated as examples of new methods to study the cardiovascular system. Preliminary results in three calves suggest that synchronous ventricular pumping is not required for total circulatory maintenance. In four calves a passive artificial right atrium was shown to decrease outflow obstruction to the right ventricle. A compliant inner deiapragm demonstrated a reduction in the amplitude of the atrial C and V waves. The effects of volume and drug infusion on peripheral vascular response in the presence of controlled artificial heart pumping (which does not respond to direct neural or hormonal influences) further illustrate the efficacy of this preparation as a new model for cardiovascular research.
人工心脏开发技术的改进以及在未麻醉小牛身上进行的植入研究，激发了一种新的心血管研究模型。独立控制左心室和右心室，用人工心房（带有顺应性内部隔膜）替代天然右心房，这些都被作为研究心血管系统新方法的示例。对三头小牛的初步研究结果表明，维持全身循环并不需要心室同步泵血。在四头小牛身上，一个被动人工右心房被证明可减少右心室的流出道梗阻。一个顺应性内部隔膜显示出心房C波和V波的幅度有所降低。在人工心脏进行控制性泵血（不受直接神经或激素影响）的情况下，容量和药物输注对外周血管反应的影响，进一步证明了这种实验准备作为心血管研究新模型的有效性。
