Neal C P, Freestone P P, Maggs A F, Haigh R D, Williams P H, Lyte M
FEMS Microbiol Lett. 2001 Jan 15;194(2):163-9. doi: 10.1111/j.1574-6968.2001.tb09463.x.
Drugs commonly used in intensive care settings were assayed for their ability to affect the growth of Staphylococcus epidermidis in a minimal salts medium containing 30% serum. Of 28 compounds tested, the inotropic catecholamines adrenaline, dobutamine, dopamine, isoprenaline and noradrenaline significantly stimulated bacterial growth. These drugs, but not structurally similar compounds lacking a dihydroxybenzoyl moiety (such as tyramine, phenylephrine and salbutamol), were able to remove iron from iron-saturated transferrin and to supply transferrin-bound 55Fe to S. epidermidis cells. Similar results were observed with a range of coagulase-negative staphylococci associated with line infections, but not with Staphylococcus aureus (including MRSA).
对重症监护环境中常用的药物进行了检测，以评估它们在含有30%血清的最低盐培养基中影响表皮葡萄球菌生长的能力。在测试的28种化合物中，强心儿茶酚胺类药物肾上腺素、多巴酚丁胺、多巴胺、异丙肾上腺素和去甲肾上腺素显著刺激细菌生长。这些药物，而不是缺乏二羟基苯甲酰部分的结构类似化合物（如酪胺、去氧肾上腺素和沙丁胺醇），能够从铁饱和转铁蛋白中去除铁，并将与转铁蛋白结合的55Fe供应给表皮葡萄球菌细胞。在一系列与导管相关感染有关的凝固酶阴性葡萄球菌中观察到了类似结果，但在金黄色葡萄球菌（包括耐甲氧西林金黄色葡萄球菌）中未观察到类似结果。
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