Tournier J N, Mathieu J, Mailfert Y, Multon E, Drouet C, Jouan A, Drouet E
Départements de biologie des agents transmissibles et de radiobiologie, CRSSA, 38702 La Tronche, France.
Immunology. 2001 Jan;102(1):87-93. doi: 10.1046/j.1365-2567.2001.01152.x.
Chronic stress is known to induce immunological disorders. In the present study we examined the consequences of chronic restraint stress on the immune response to tetanus toxin in mice. We investigated the repartition of subsets of lymphoid cells in blood and spleen, the functional ability of lymphocytes to proliferate and to produce cytokines, and antibody titres against tetanus toxin following stress. We report discordance of the stimulation index of lymphocytes in the restraint group: the proliferating rate severely decreased following stimulation with a relevant antigen, whereas it increased with mitogen. Thus, we report a decrease in cytokine production with relevant antigen (interferon-gamma and interleukin-10), without a T helper type 1 and 2 secretion imbalance. Moreover, we observed an alteration in the humoral response, including a delay in isotype maturation and an immunoglobulin G1/G2a imbalance.
已知慢性应激会诱发免疫紊乱。在本研究中，我们检测了慢性束缚应激对小鼠破伤风毒素免疫反应的影响。我们研究了血液和脾脏中淋巴细胞亚群的分布、淋巴细胞增殖及产生细胞因子的功能能力，以及应激后抗破伤风毒素的抗体滴度。我们报告了束缚组淋巴细胞刺激指数的不一致性：用相关抗原刺激后增殖率严重降低，而用丝裂原刺激时增殖率增加。因此，我们报告了相关抗原刺激下细胞因子产生减少（γ干扰素和白细胞介素-10），且不存在1型和2型辅助性T细胞分泌失衡。此外，我们观察到体液反应发生改变，包括同种型成熟延迟和免疫球蛋白G1/G2a失衡。
