人类中自然杀伤细胞活性与恒河猴抗原的关系。
Relationship of natural killer-cell activity to rhesus antigens in man.
作者信息
Hersey P, Edwards A, Trilivas C, Shaw H, Milton G W
出版信息
Br J Cancer. 1979 Mar;39(3):234-40. doi: 10.1038/bjc.1979.46.
A number of previous studies have shown that the level of natural killer (NK) cell activity in humans is relatively constant for a given individual but varies widely between individuals. The factors which determine this variability are largely unknown, but genetic factors appear to be involved. In the present study it was found that Rh- normal subjects and melanoma patients had significantly higher natural cytotoxicity to target cells than Rh+ patients. This difference did not appear to be due to sensitization against Rh antigens on the target cell and may indicate that genes determining NK-cell activity are associated with those determining the expression of Rh antigens. Analysis of the survival data for Rh- and Rh+ patients did not reveal any increase in survival attributable to the higher natural cytotoxicity in Rh- patients.
此前的多项研究表明，对于特定个体而言，人类自然杀伤（NK）细胞活性水平相对稳定，但个体之间差异很大。决定这种变异性的因素大多未知，但似乎涉及遗传因素。在本研究中发现，Rh阴性正常受试者和黑色素瘤患者对靶细胞的自然细胞毒性明显高于Rh阳性患者。这种差异似乎并非由于对靶细胞上Rh抗原的致敏作用，可能表明决定NK细胞活性的基因与决定Rh抗原表达的基因相关。对Rh阴性和Rh阳性患者生存数据的分析未发现Rh阴性患者较高的自然细胞毒性使其生存率有所提高。
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