进行性系统性硬化症中的自然杀伤细胞活性和抗体依赖性细胞毒性
Natural killer activity and antibody-dependent cellular cytotoxicity in progressive systemic sclerosis.
作者信息
Grazia Cifone M, Giacomelli R, Famularo G, Paolini R, Danese C, Napolitano T, Procopio A, Perego A M, Santoni A, Tonietti G
机构信息
Department of Expermental Medicine, University of L'Aquila, Italy.
出版信息
Clin Exp Immunol. 1990 Jun;80(3):360-5. doi: 10.1111/j.1365-2249.1990.tb03293.x.
Abstract
Enhanced natural killer (NK) activity and normal lymphocyte antibody-dependent cellular cytotoxicity (ADCC) were observed in 16 patients with a diagnosis of progressive systemic sclerosis (PSS). Higher NK activity levels were observed against NK-sensitive K562 target cells, while the NK-resistant P815, Daudi and Raji cell lines were not lysed. Cytofluorimetric studies and morphological analysis of peripheral blood lymphocytes (PBL) showed an increased number of CD16 positive cells and large granular lymphocytes (LGL), indicating that the enhancement observed was probably attributable to an increase in the number of circulating NK cells.
摘要
在16例诊断为进行性系统性硬化症（PSS）的患者中观察到自然杀伤（NK）活性增强以及正常淋巴细胞抗体依赖性细胞毒性（ADCC）。针对NK敏感的K562靶细胞观察到较高的NK活性水平，而对NK抗性的P815、Daudi和Raji细胞系未出现裂解。外周血淋巴细胞（PBL）的细胞荧光分析和形态学分析显示CD16阳性细胞和大颗粒淋巴细胞（LGL）数量增加，表明观察到的增强可能归因于循环NK细胞数量的增加。
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