Takasugi M, Ramseyer A, Takasugi J
Cancer Res. 1977 Feb;37(2):413-8.
Lymphocytes isolated from the blood of patients and healthy donors include a population of cells that destroy target cells in the direct cell-mediated cytotoxic assay with little indication of specificity. This natural reaction is the dominant feature of most cell-mediated cytotoxic tests and, although it appears to be mostly nonselective, it possesses some selective activity. The observed cytotoxicity from these reactions depends mostly on the reactivity of the effector cell; when several effector cells are tested on different target cells, the relative order of activity is usually maintained on the different target cells. When this natural cytotoxicity was analyzed without regard to the type of cancer of the patient or of the target cells, a weak decline in the average reactivity was observed with increasing tumor involvement.
从患者和健康供体血液中分离出的淋巴细胞包含一群细胞，这些细胞在直接细胞介导的细胞毒性试验中可破坏靶细胞，几乎没有特异性迹象。这种天然反应是大多数细胞介导的细胞毒性试验的主要特征，尽管它似乎大多是非选择性的，但仍具有一些选择性活性。这些反应中观察到的细胞毒性主要取决于效应细胞的反应性；当在不同靶细胞上测试多个效应细胞时，活性的相对顺序通常在不同靶细胞上保持不变。在不考虑患者癌症类型或靶细胞类型的情况下分析这种天然细胞毒性时，随着肿瘤累及程度的增加，观察到平均反应性略有下降。
