Bremer W
Histochemistry. 1975;41(3):265-74. doi: 10.1007/BF00497690.
Using the histochemical reaction for acid phosphatase the lysosomal pattern of the proximal renal tubule has been investigated in virginal female rats, in the course of pregnancy, and in females following pretreatment with progesterone. Furthermore the stage of gestation, phases of sexual cycle, the urinary output as well its protein concentration and the protein excretion have been taken into account. From the metabolic studies it becomes clear, that the urine values depend on the sexual phase and the duration of gravidity. On the basis of our histochemical results strong evidence occurs, that the lysosomes in the proximal renal tubule are influenced by both, the proteins in the primary urine and by sex hormones. In all collectives investigated an increase of the protein concentrations in the urine runs always parallel to an increase of the number of small and medium-sized lysosomes; the big ones disappear. At the end of pregnancy and after pretreatment with progesterone acid phosphatase seems to diffuse out of the lysosomes in the epithelial cells of the S1- and S2-segments.
利用酸性磷酸酶的组织化学反应，对未交配的雌性大鼠、妊娠期间以及用孕酮预处理后的雌性大鼠近端肾小管的溶酶体模式进行了研究。此外，还考虑了妊娠阶段、性周期阶段、尿量及其蛋白质浓度和蛋白质排泄情况。从代谢研究中可以清楚地看出，尿液值取决于性阶段和妊娠持续时间。根据我们的组织化学结果，有强有力的证据表明，近端肾小管中的溶酶体受到原尿中的蛋白质和性激素两者的影响。在所有研究的群体中，尿液中蛋白质浓度的增加总是与中小型溶酶体数量的增加平行；大型溶酶体消失。在妊娠末期和用孕酮预处理后，酸性磷酸酶似乎从S1和S2段上皮细胞的溶酶体中扩散出来。
