Prival M J
Genetic Toxicology Branch (HFS-236), Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
Environ Mol Mutagen. 2001;37(1):55-69. doi: 10.1002/1098-2280(2001)37:1<55::aid-em1006>3.0.co;2-5.
The TOPKAT computer-based system for predicting chemical carcinogens was evaluated by determining its ability to predict the carcinogenicity of chemicals tested by the National Toxicology Program. TOPKAT was not effective in identifying potential rodent carcinogens and noncarcinogens in the data set analyzed. The chemicals in the TOPKAT database of known carcinogens and noncarcinogens that the software identifies as most "similar" to unknown chemicals are illustrated using six examples. These "similar" chemicals generally bear no apparent relationship to the chemical of interest with regard to metabolism or potential mechanism of carcinogenicity. Environ. Mol. Mutagen. 37:55-69, 2001 Published 2001 Wiley-Liss, Inc.
通过测定其预测美国国家毒理学计划所测试化学物质致癌性的能力，对基于计算机的TOPKAT化学致癌物预测系统进行了评估。在分析的数据集中，TOPKAT在识别潜在的啮齿动物致癌物和非致癌物方面效果不佳。使用六个例子说明了TOPKAT数据库中已知致癌物和非致癌物中被该软件识别为与未知化学物质最“相似”的化学物质。就代谢或潜在致癌机制而言，这些“相似”化学物质通常与所关注的化学物质没有明显关系。《环境与分子突变》37:55 - 69，2001年出版 2001年威利 - 利斯公司版权所有
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