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恒河猴实验性视网膜分支静脉阻塞。III. 组织病理学和电子显微镜研究。

Experimental retinal branch vein occlusion in rhesus monkeys. III. Histopathological and electron microscopical studies.

作者信息

Hockley D J, Tripathi R C, Ashton N

出版信息

Br J Ophthalmol. 1979 Jun;63(6):393-411. doi: 10.1136/bjo.63.6.393.

DOI:10.1136/bjo.63.6.393
PMID:111703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043499/
Abstract

Experimental retinal vein occlusion in monkeys was followed by an immediate increase in capillary permeability which was accompanied by retinal oedema. This functional capillary change was followed at about 6 hours after occlusion by structural damage to the capillary wall. Thrombus formation occurred in the damaged vessels, and areas of stasis were thus produced with associated retinal haemorrhages. Finally, there was complete loss of the capillary endothelium and pericytes, and the acellular capillaries were invaded by proliferating glial cell processes, so producing permanent capillary closure.

摘要

猴子实验性视网膜静脉阻塞后，毛细血管通透性立即增加，并伴有视网膜水肿。这种功能性毛细血管变化在阻塞后约6小时，随之出现毛细血管壁的结构损伤。受损血管中形成血栓，从而产生血流淤滞区域并伴有视网膜出血。最后，毛细血管内皮细胞和周细胞完全丧失，无细胞毛细血管被增生的神经胶质细胞突起侵入，从而导致毛细血管永久性闭合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/21fb4f460ff8/brjopthal00210-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/1f316ebd5bdf/brjopthal00210-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/656f10c500fd/brjopthal00210-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/c1d0df97c04d/brjopthal00210-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/f816b67e57a9/brjopthal00210-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/38ba69b5a734/brjopthal00210-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/20c5f132022b/brjopthal00210-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/0f87aa269ba4/brjopthal00210-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/abca64e09c5b/brjopthal00210-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/689061851cfc/brjopthal00210-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/21fb4f460ff8/brjopthal00210-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/1f316ebd5bdf/brjopthal00210-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/656f10c500fd/brjopthal00210-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/c1d0df97c04d/brjopthal00210-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/f816b67e57a9/brjopthal00210-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/38ba69b5a734/brjopthal00210-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/20c5f132022b/brjopthal00210-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/0f87aa269ba4/brjopthal00210-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/abca64e09c5b/brjopthal00210-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/689061851cfc/brjopthal00210-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9798/1043499/21fb4f460ff8/brjopthal00210-0034-a.jpg

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STUDIES OF THE RETINAL CAPILLARIES IN RELATION TO DIABETIC AND OTHER RETINOPATHIES.视网膜毛细血管与糖尿病及其他视网膜病变的相关性研究。
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Diabetic retinopathy: a new approach.糖尿病视网膜病变：一种新方法。
VEGFR1 信号在视网膜血管生成和微炎症中的作用。
Prog Retin Eye Res. 2021 Sep;84:100954. doi: 10.1016/j.preteyeres.2021.100954. Epub 2021 Feb 25.
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Multimodal Imaging of Microvascular Abnormalities in Retinal Vein Occlusion.视网膜静脉阻塞微血管异常的多模态成像
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Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts.为何棉絮斑不应被视为视网膜神经纤维层梗死。
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