Hamilton A M, Kohner E M, Rosen D, Bird A C, Dollery C T
Br J Ophthalmol. 1979 Jun;63(6):377-87. doi: 10.1136/bjo.63.6.377.
Branch and hemisphere vein occlusion were produced in rhesus monkeys by argon laser photocoagulation. The following observations were made: (1) Immediately after occlusion there was venous dilatation, delayed filling of the artery, delayed drainage by the occluded vein, and capillary leakage. (2) Two patterns of evolution were identified within the first week. In some animals the fundus changes resolved and the retina returned to normal, while in others there was progressive retinal capillary closure. (3) Those animals destined to have capillary closure had diffuse or cluster retinal haemorrhages at 24 hours. (4) Capillary closure took place over 1 week and was usually complete over large areas of retina. (5) Retinal atrophy and major vessel changes occurred over several weeks. (6) Retinal revascularisation occurred in those areas of closure, though this was often limited. It was concluded that the early changes mimicked those seen in human retinal vein occlusion, though persistent retinal oedema and preretinal neovascularisation were not identified.
通过氩激光光凝术在恒河猴身上造成分支静脉和半球静脉阻塞。观察到以下情况：(1) 阻塞后立即出现静脉扩张、动脉充盈延迟、阻塞静脉引流延迟以及毛细血管渗漏。(2) 在第一周内确定了两种演变模式。在一些动物中，眼底变化消退，视网膜恢复正常，而在另一些动物中则出现进行性视网膜毛细血管闭塞。(3) 那些注定会发生毛细血管闭塞的动物在24小时时出现弥漫性或簇状视网膜出血。(4) 毛细血管闭塞在1周内发生，通常在视网膜的大片区域完全形成。(5) 视网膜萎缩和主要血管变化在数周内出现。(6) 在闭塞区域发生了视网膜血管再生，尽管通常很有限。得出的结论是，早期变化与人类视网膜静脉阻塞所见相似，尽管未发现持续性视网膜水肿和视网膜前新生血管形成。
