虎眼万年青鳞茎中的细胞毒性胆甾烷糖苷。

Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae.

作者信息

Kuroda M, Mimaki Y, Yokosuka A, Sashida Y, Beutler J A

机构信息

Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.

出版信息

J Nat Prod. 2001 Jan;64(1):88-91. doi: 10.1021/np0003084.

DOI:10.1021/np0003084

Abstract

Further phytochemical analysis of the bulbs of Ornithogalum saundersiae has yielded two new cytotoxic cholestane triglycosides (1 and 2). The structures of these compounds were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and the results of hydrolytic cleavage. Compounds 1 and 2 and several analogues were evaluated for their cytotoxicity against HL-60 cells.

摘要

对虎眼万年青鳞茎进行的进一步植物化学分析得到了两种新的具有细胞毒性的胆甾烷三糖苷（1和2）。通过光谱分析，包括二维核磁共振光谱数据以及水解裂解结果，确定了这些化合物的结构。对化合物1和2以及几种类似物针对HL-60细胞的细胞毒性进行了评估。

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