生物素化OSW-1的合成
Synthesis of biotinylated OSW-1.
作者信息
Kang Ying, Lou Changgang, Ahmed Kausar Begam Riaz, Huang Peng, Jin Zhendong
机构信息
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
出版信息
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5166-8. doi: 10.1016/j.bmcl.2009.07.062. Epub 2009 Jul 14.
Abstract
OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.
摘要
OSW-1是一种高效的具有未知作用模式的抗癌天然皂苷。为了确定其细胞靶点，通过九步成功合成了生物素化的OSW-1。
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本文引用的文献
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A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: total synthesis of a highly potent antitumor natural product OSW-1.一种通过α-烷氧基乙烯基铜酸盐立体选择性引入甾体侧链的新策略：高效抗肿瘤天然产物OSW-1的全合成。
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