van Der Kaaden J E, Hemscheidt T K, Mooberry S L
Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii, 96822, USA.
J Nat Prod. 2001 Jan;64(1):103-5. doi: 10.1021/np000265r.
A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC(50) value of 1.3 microM in both cases.
通过生物活性导向分离法，从血桐叶中分离出一种新的异戊烯基化芪类化合物——血桐素（1）。通过光谱方法确定了其结构。血桐素具有细胞毒性，但它似乎不是P-糖蛋白介导转运的良好底物，因为它对药物敏感的SK-OV-3和耐药的SKVLB-1卵巢癌细胞系具有同等效力和效果，在两种情况下的半数抑制浓度（IC50）值均为1.3微摩尔。
