Dai J, Carté B K, Sidebottom P J, Sek Yew A L, Ng S, Huang Y, Butler M S
Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore.
J Nat Prod. 2001 Jan;64(1):125-6. doi: 10.1021/np000381u.
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.
发现赭曲霉肉汤的粗提取物可抑制丙型肝炎病毒复制过程中多蛋白加工的最后阶段。生物测定引导的分级分离导致分离出已知化合物麦角硫因作为提取物的活性成分。还分离出了环孢菌素F和一种新的生物碱环孢菌素G。通过光谱分析确定了环孢菌素G的结构。
