Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus.

作者信息

López-Gresa M Pilar, González M Carmen, Primo Jaime, Moya Pilar, Romero Vanessa, Estornell Ernesto

机构信息

Centro de Ecologia Química Agrícola, Universidad Politécnica de Valencia, Campus de Vera, Edificio 9B, Laboratorio 111, Valencia, Spain.

出版信息

J Antibiot (Tokyo). 2005 Jun;58(6):416-9. doi: 10.1038/ja.2005.54.

DOI:10.1038/ja.2005.54

PMID:16156520

Abstract

Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.

摘要