Shearer T R
J Nutr. 1975 Mar;105(3):338-47. doi: 10.1093/jn/105.3.338.
The mechanism for the uptake of dietary inorganic and organic selenium by the fully developed, mature molar teeth of mother rats and the developing molar teeth of their pups was studied. Pregnant rats received drinking solutions containing either 0.2 ppm Na2SiO3 plus 0.043 muCi Na2-75SeO3 per ml from day 10 of pregnancy until parturition. Thirteen days postpartum, the uptake of dietary 75Se into developing molar teeth was more extensive than the postdevelopmental uptake onto mature teeth. Developing molar teeth incorporated more 75Se from dietary selenomethionine than from selenite, as did many hard and soft tissues studied. The major portion of 75Se in enamel and dentine was located in the protein fraction of these dental tissues. Dialysis experiments showed that the selenium in enamel and dentine existed in at least three forms: loosely bound selenium, proteinaceous selenotrisulfides, and proteinaceous stable selenium. These data and the results of a previous study (J. Nutr. 103, 553-559) provide evidence that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietary selenium.
研究了母鼠发育完全、成熟的磨牙以及幼崽发育中的磨牙摄取膳食无机硒和有机硒的机制。从怀孕第10天到分娩，怀孕大鼠饮用每毫升含0.2 ppm Na2SiO3加0.043 μCi Na2-75SeO3的溶液。产后13天，发育中的磨牙对膳食75Se的摄取比对成熟牙齿的发育后摄取更广泛。发育中的磨牙从膳食硒代蛋氨酸中摄取的75Se比从亚硒酸盐中摄取的更多，许多研究的硬组织和软组织也是如此。牙釉质和牙本质中75Se的主要部分位于这些牙齿组织的蛋白质部分。透析实验表明，牙釉质和牙本质中的硒至少以三种形式存在：松散结合的硒、蛋白质硒三硫化物和蛋白质稳定硒。这些数据以及先前一项研究（《营养学杂志》103，553 - 559）的结果提供了证据，即作为硒三硫化物或硒氨基酸掺入发育中蛋白质的硒可能是导致人类和实验动物摄入稍多膳食硒后龋齿增加的原因。
