Soloway M S, Cohen S M, Dekernion J B, Persky L
J Urol. 1975 Apr;113(4):483-6. doi: 10.1016/s0022-5347(17)59506-3.
L-ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. We evaluated whether L-ascorbic acid given concomitantly with the urinary carcinogen FANFT was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L-ascorbic acid its routine administration to patients with bladder cancer is not indicated.
已证明L-抗坏血酸可降低膀胱癌患者尿液中升高的化学发光水平。因此，有人提出维生素C可能对预防膀胱肿瘤有效。然而，尚无临床证据支持这一论点。我们评估了L-抗坏血酸与尿液致癌物FANFT同时使用是否能够降低后续膀胱肿瘤的发生率。未观察到抑制作用。除非获得证据证明L-抗坏血酸可预防膀胱肿瘤，否则不建议对膀胱癌患者常规使用L-抗坏血酸。
