Gerard C, Rollins B J
Department of Pediatrics, Perlmutter Laboratory, Children's Hospital, Boston, MA, USA.
Nat Immunol. 2001 Feb;2(2):108-15. doi: 10.1038/84209.
We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.
我们在此研究几种与趋化因子网络不适当激活相关的疾病。详细评论仅限于那些从临床观察或动物模型中获得确凿数据的病理状态。这些疾病包括心血管疾病、过敏性炎症疾病、移植、神经炎症、癌症以及与HIV相关的疾病。讨论聚焦于快速发展的趋化因子领域可能的治疗方向。
