Senkan Selim
Department of Chemical Engineering University of California Los Angeles, CA 90095 (USA).
Angew Chem Int Ed Engl. 2001 Jan 19;40(2):312-329.
Combinatorial catalysis is the systematic preparation, processing, and testing of large diversities of chemically and physically different materials libraries in a high-throughput fashion. It also embodies microfabrication, robotics, automation, instrumentation, computational chemistry, and large-scale information management (informatics), and as such carries the promise of a renaissance in catalytic reaction engineering. Significant progress has already been made in demonstrating the speed and economic advantage of combinatorial approaches by the discovery of superior catalytic materials in a matter of hours and days, as opposed to the months and years required using traditional methods. Combinatorial methods can also significantly contribute to our understanding of catalytic function by increasing our chances of discovering totally new and unexpected catalytic materials, and by expediting the recognition of trends and patterns of structure-activity relations, from which new catalytic materials can be designed more efficiently. Combinatorial catalysis undoubtedly will be the new paradigm of catalysis research as the industry faces increasing global competition and pressure for the development of environmentally friendly processes at a time when resources for research are diminishing.
组合催化是以高通量方式对大量化学和物理性质不同的材料库进行系统制备、处理和测试。它还涵盖了微制造、机器人技术、自动化、仪器仪表、计算化学和大规模信息管理(信息学),因此有望推动催化反应工程的复兴。通过在数小时或数天内发现优异的催化材料,与传统方法所需的数月甚至数年相比,组合方法已在展示其速度和经济优势方面取得了重大进展。组合方法还可以通过增加发现全新和意外催化材料的机会,以及加快对结构-活性关系趋势和模式的认识,从而显著促进我们对催化功能的理解,进而更有效地设计新的催化材料。随着行业面临日益激烈的全球竞争以及在研究资源减少的情况下开发环境友好工艺的压力,组合催化无疑将成为催化研究的新范式。