Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208.
International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208.
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):40-45. doi: 10.1073/pnas.1815358116. Epub 2018 Dec 17.
The nanomaterial landscape is so vast that a high-throughput combinatorial approach is required to understand structure-function relationships. To address this challenge, an approach for the synthesis and screening of megalibraries of unique nanoscale features (>10,000,000) with tailorable location, size, and composition has been developed. Polymer pen lithography, a parallel lithographic technique, is combined with an ink spray-coating method to create pen arrays, where each pen has a different but deliberately chosen quantity and composition of ink. With this technique, gradients of Au-Cu bimetallic nanoparticles have been synthesized and then screened for activity by in situ Raman spectroscopy with respect to single-walled carbon nanotube (SWNT) growth. AuCu, a composition not previously known to catalyze SWNT growth, has been identified as the most active composition.
纳米材料领域非常广阔，需要采用高通量组合方法来了解结构与功能关系。为了解决这一挑战，人们开发了一种独特的纳米级特征（>10,000,000）的兆级库的合成和筛选方法，这些特征具有可定制的位置、尺寸和组成。聚合物笔式光刻技术是一种平行光刻技术，与喷墨涂层方法相结合，可创建笔式阵列，其中每支笔都具有不同但经过精心选择的油墨数量和组成。使用这种技术，可以合成金-铜双金属纳米粒子的梯度，然后通过原位拉曼光谱法对其进行活性筛选，以观察单壁碳纳米管（SWNT）的生长情况。AuCu 是一种以前未知的能够催化 SWNT 生长的成分，被确定为最活跃的成分。
