Vicens B, Reventos J, Cornudella R
Respiration. 1975;32(2):112-20. doi: 10.1159/000193641.
One stage total bilateral pulmonary denervation produced in a group of 23 dogs an increase breathing frequency, an increase in the amplitude of respiration and a characteristic morphology of the spirographic pattern. Later in the evolution, these alterations returned to normal with the exeption of the amplitude of respiration which remained increased. This normalization was not accompanied by the reappearance of the Hering-Breuer reflux. Administration of an aerosol of acetylcholine after normalization of the spirographic pattern produced a temporary reappearance of the immediate postdenervation spirographic pattern. We postulate that in denervated lung a nervous plexus localized in the bronchi not related to the vagus might assume an important role in the regulation of respiration. One cannot exclude, however, the possibility that the reappearance of postdenervation pattern is due to stimulation of airways vagal receptors located in areas proximal to the level of the nervous section.
在一组23只狗身上进行的一期双侧全肺去神经支配术，导致呼吸频率增加、呼吸幅度增大以及呼吸描记图出现特征性形态。在后期演变过程中，除呼吸幅度仍增大外，这些改变恢复正常。这种恢复正常并未伴随黑林-布雷尔反射的重新出现。呼吸描记图恢复正常后给予乙酰胆碱气雾剂，可使去神经支配后即刻的呼吸描记图暂时重现。我们推测，在去神经支配的肺中，位于支气管且与迷走神经无关的神经丛可能在呼吸调节中起重要作用。然而，不能排除去神经支配后模式重现是由于刺激了位于神经切断水平近端区域的气道迷走神经受体的可能性。
